The vagus nerve is made up of an intricate neural network that maintains homeostasis and equilibrium in important processes as well as interfacing with inflammatory, autonomic, mood and pain regulation. Learn how we are utilising the neuromodulatory effects of the vagus nerve to improve patient outcomes and increase quality of life.

Approach

Atrial

Fibrillation ​

 

TREAT AF II: A Randomised Clinical Trial

EXPECTED 2022

 

BRIDGE AF: A Randomised Clinical Trial

ONGOING

 

TREAT AF (Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Atrial Fibrillation): A Randomised Clinical Trial

Stavrakis et al. Clinical Electrophysiology 2020

 

Low-level transcutaneous electrical vagus nerve stimulation suppresses atrial fibrillation.

Stavrakis et al. JACC 2015

 

Low-level vagus nerve stimulation suppresses post-operative atrial fibrillation and inflammation: a randomised study

Stavrakis et al. JACC 2017

 

 

Heart

Failure ​

 

TREAT-HF Low Level Tragus Stimulation in Acute Decompensated Heart Failure: A Randomized Clinical Trial 

Ongoing 

 

TRANSFER HF: A Randomized Clinical Trial Ongoing 

Ongoing 

 

TECO-HF (Neuromodulation of Inflammation and Vascular Function in Systolic Heart Failure): A Randomized Clinical Trial 

Ongoing 

 

Neuromodulation to Treat Patients With Heart Failure With Preserved Ejection Fraction

Completed 2021

 

Effects of low-level tragus stimulation on endothelial function in heart failure with reduced ejection fraction

Dasari et al. Journal of Cardiac Failure 2021

 

Non-invasive neuromodulation of vagus activity improves endothelial function in patients with heart failure with reduced ejection fraction: a randomised study 

Dasari et al. Journal of Cardiac Failure 2018

 

Autonomic neuromodulation acutely ameliorates left ventricular strain in humans

Tran et al. J Cardiovascular Translational Research 2018

 

Low level transcutaneous vagus nerve stimulation acutely ameliorates diastolic function in humans

Stavrakis et al. European Heart Journal 2017

 

 

 

Neuro

 

 

Non-Invasive vagal nerve stimulation in autonomic disorders

Ongoing

  

Non-Invasive vagal nerve stimulation in Long Covid syndrome

Expected 2022

 

Vagus Nerve Stimulation as a Treatment of Long Covid

Expected 2022

 

Transcutaneous Auricular Vagus Nerve Stimulation (tVNS) can Reverse the Manifestations of the Long-COVID Syndrome: A Pilot Study

Verbanck et al. Frontiers in Neurology and Neuroscience 2021

 

Feasibility, safety and efficacy of transauricular vagus nerve stimulation in a cohort of patients with disorders of consciousness    

Noe et al. Brain Stimulation 2019 

 

Non-invasive vagus nerve stimulation reduces sympathetic preponderance in patients with tinnitus 

Ylikoski et al.  Acta oto-laryngologica 2017

 

Neuro-

enhancement

 

Improvement of memory-based reading recall using transcutaneous auricular vagus nerve stimulation     

Thakkar et al. 2021 

 

The effects of taVNS on novel language learning in young adults 

Thakkar et al. 2020

 

The effect of transcutaneous auricular vagus nerve stimulation on reading comprehension 

Richardson et al. 2020

 

 

 

 

Science of Modulating the Vagus Nerve​

 ​

Experimental

 

 

Transcutaneous vagal nerve stimulation synergizes with radiotherapy by ameliorating the anti-tumor response in lung cancer     

Completed

 

Effects of non-invasive vagal nerve stimulation on radiation-induced inflammation and cancer prognosis     

Reijmen et al. 2020 

 

+ >20 Stealth Studies